The use of lamotrigine in juvenile myoclonic epilepsy
نویسنده
چکیده
Lamotrigine (LTG) was used in 12 patients with juvenile myoclonic epilepsy (JME) who either had sodium valproate (VPA) side effects or did not wish to take VPA. Five patients are now fully controlled on LTG monotherapy. Side-effects were corrected by VPA withdrawal or reduction except for severe weight gain. In three patients it was not possible to withdraw VPA due to the re-emergence of myoclonus, suggesting LTG-VPA synergism. Two patients had successful pregnancies whilst taking LTG. Lamotrigine is a useful alternative in the management of JME.
منابع مشابه
Juvenile myoclonic epilepsy.
2. In treatment of juvenile myoclonic epilepsy, the following is true except: a. Phenobarbitone is an effective treatment for generalized tonic seizures and myoclonic seizures b. Lamotrigine exaggerates myoclonic seizures in 50% of patients c. Levetiracetam has potent antimyoclonic effects d. Life long treatment with a proper AED is recommended for juvenile myoclonic epilepsy e. Pregabalin is a...
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Lacosamide is a new-generation antiseizure medication that is approved for use as an adjunctive treatment and monotherapy in focal epilepsy. Its use in generalized epilepsy, however, has not been adequately evaluated in controlled trials. We report a 67-year-old woman who experienced new-onset myoclonic seizures after initiation of lacosamide. We presume that she had an undiagnosed generalized ...
متن کاملEfficacy and tolerability of lamotrigine in Juvenile Myoclonic Epilepsy in adults: A prospective, unblinded randomized controlled trial
PURPOSE Controlled randomized studies recommending the clinical use of lamotrigine in adult populations with the diagnosis of Juvenile Myoclonic Epilepsy are still lacking. To compare the efficacy and tolerability of lamotrigine versus valproate in adult patients with JME. METHODS This was a prospective, randomized, controlled, pragmatic, long-term and open-label treatment trial. Patients wer...
متن کاملLacosamide treatment of juvenile myoclonic epilepsy
Juvenile myoclonic epilepsy is the most common form of idiopathic generalized epilepsy with onset at puberty or late teenage years. About 80-90% of patients with juvenile myoclonic epilepsy respond to appropriate antiepileptic treatment and achieve seizure freedom, and about 15% of patients become intractable. Valproic acid, levetiracetam, lamotrigine, topiramate and zonisamide are used as firs...
متن کاملEvolving antiepileptic drug treatment in juvenile myoclonic epilepsy.
BACKGROUND In the face of availability of newer antiepileptic drugs (AEDs) such as lamotrigine and topiramate, there is need to reassess the role of older AEDs in the treatment of juvenile myoclonic epilepsy (JME). OBJECTIVES To explore whether lamotrigine and topiramate monotherapy or polytherapy can be effective options in the treatment of JME, and to determine whether older AEDs, such as p...
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عنوان ژورنال:
- Seizure
دوره 5 شماره
صفحات -
تاریخ انتشار 1996